Depression is a risk factor for incident coronary heart disease in women: An 18-year longitudinal study

A O'Neil; AJ Fisher; KJ Kibbey; FN Jacka; MA Kotowicz; LJ Williams; AL Stuart; M Berk; PA Lewandowski; CB Taylor; JA Pasco

Journal article

Depression is a risk factor for incident coronary heart disease in women: An 18-year longitudinal study

A O'Neil, AJ Fisher, KJ Kibbey, FN Jacka, MA Kotowicz, LJ Williams, AL Stuart, M Berk, PA Lewandowski, CB Taylor, JA Pasco

Journal of Affective Disorders | ELSEVIER SCIENCE BV | Published : 2016

DOI: 10.1016/j.jad.2016.02.029

Abstract

Background: According to a recent position paper by the American Heart Association, it remains unclear whether depression is a risk factor for incident Coronary Heart Disease (CHD). We assessed whether a depressive disorder independently predicts 18-year incident CHD in women. Method A prospective longitudinal study of 860 women enrolled in the Geelong Osteoporosis Study (1993-2011) was conducted. Participants were derived from an age-stratified, representative sample of women (20-94 years) randomly selected from electoral rolls in South-Eastern Australia. The exposure was a diagnosis of a depressive disorder using the Structured Clinical Interview for Diagnostic and Statistical Manual of Me..

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Prof Michael Berk Author

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Funding Acknowledgements

The GOS was supported by grants from the Victorian Health Promotion Foundation and the NHMRC (Projects 251638, 454356, 509103 and 628582) as well as Deakin University Central Grants Scheme. The funders had no influence on the enactment or results of the study.